ea0038p384 | Steroids | SFEBES2015
Gilligan Lorna
, Nguyen Mai
, Hewitt Anne-Marie
, Burnell Kirsty
, Rahman Habibur
, Hardy Rowan
, Foster Paul
Steroid sulphatase (STS) is the primary enzyme for desulphating steroids from their inactive to their active forms. Principal substrates include steroid precursors oestrone-sulphate and dehydroepiandrosterone sulfate. Alterations in STS activity can directly affect local concentrations of oestradiol, testosterone and dihydrotestosterone; steroids that are frequently dysregulated in disease. Despite the importance of STS activity on steroid synthesis, little is known about its ...